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Issue 2006-03, March 2006

Local Coverage Determinations (LCD) Summary

Providers: If you wish to obtain the full text of the LCDs (and articles) described in this section, they are available on the Empire Medicare Services Web site at http://www.empiremedicare.com/PartA/ parta_lcd.cfm.

Read and accept the CPT License for Use, then click on the “Policies in Notice Period” link or write to:

Empire Medicare Services
P. O. Box 4846
Syracuse, NY 13221-4846
Attention: Coordination Department

Or call the Empire Medicare Services Provider Inquiries Department at:
1-877-567-7205.

To receive notification when new policies or updates are posted to our Web site, subscribe to the Empire Medicare Services Local Coverage Determination (LCD) mailing list from the EMS Web site at: http://www.empiremedicare.com/PartA/parta_lcd.cfm. Just read and accept the CPT License for Use, click on the appropriate “subscribe to mailing list” link and fill in the requested information.

Local Coverage Determination

The Local Coverage Determination (LCD) identified below will be effective April 17, 2006.

Beta Glucocerebrosidase and Analogues - L2206

Notice Period: 03/01/2006 - 04/16/2006
Effective Date: 04/17/2006

LCD Description:
Beta glucocerebrosidase (Ceredase®) is a semi-synthetic form of human glucosylceramidase and is prepared from pooled human placental tissue obtained from selected donors. It is missing in patients with Type I Gaucher Disease (adult type). Deficiency of this enzyme can result in lipidosis characterized by accumulation of glucosylceramide, which is highly insoluble, in storage cells in the liver, spleen, bone marrow, lymph nodes, and rarely alveolar capillaries.

Gaucher Disease is a rare, inherited, and potentially fatal disease that involves the accumulation of the lipid glucocerebroside in the lysosomes of the monocyte macrophage system. This causes the displacement of normal cells in the bone marrow, hepatosplenomegaly, organ dysfunction, anemia, thrombocytopenia, and skeletal damage. As a result, the symptoms may include abdominal swelling, incapacitating bone pain, and restricted mobility, which is the major cause of disability in adult patients with this condition.

Beta glucocerebrosidase (Ceredase®) has been shown to be effective in reversing the course of the disease. Replacement therapy is palliative in Gaucher’s disease and does not correct the underlying genetic abnormality. Therefore, the therapy must be continued indefinitely.

There are three types of Gaucher Disease which include:

  • Type I - Chronic non-neuronopathic; this is the most common type;
  • Type II - Acute neuronopathic; and
  • Type III - Sub-acute neuronopathic.

Analogues
Imiglucerase (Cerezyme®) is a recombinant DNA-derived form of the enzyme glucosylceramidase. This drug is equivalent to alglucerase (Ceredase®).

 

   
 
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